laurent75 a écrit: je ne sais pas si cette mutation implique un faible taux de vitamine D ou une mauvaise utilisation.
FUT2 Gene and the Gut Microbiome
The human microbiome consists of trillions of micro-organisms mostly in the form of bacteria in the skin, gut, and airways. They exert regulatory functions, influence energy handling, produce nutrients, and may be associated with diabetes and obesity.
The gut microbiome is involved in vital biological functions such as maintenance of immune balance, modulation of intestinal development and enhanced metabolic capabilities. Disturbances of the intestinal microbiota have been associated with development and progression of inflammatory conditions.[1,5] Individual variation in the microbiota compositions is influenced by environmental, host, dietary factors1 and the FUT2 gene.
The fucosyltransferase 2 (FUT2) gene produces an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa and has been shown to modify the gut microbiome. The H antigen acts as both an attachment site and carbon source for intestinal bacteria. Individuals lacking a functional copy of FUT2 are known as "nonsecretors" and display an array of differences in susceptibility to infection and disease, including Crohn disease.[3,4]
Your Genetics
Gene variation
Genotype
Phenotype
FUT2 rs601338
AA
+/+
Laurent75 is more likely to have lower microbiome species diversity, due to AA genotype for rs601338 compared to people with other genotypes. Other clinical, genetic or environmental factors may influence this outcome.
Non-secretors, are homozygous for the loss-of-function alleles of FUT2 gene, which could cause increased susceptibility to inflammatory conditions including Crohn disease3. A study of non-secretor (FUT2 rs601338 AA genotype) and secretor (GG and AG genotypes) adults of western European descent showed that non-secretors had lower species richness than the secretors, and that secretor status and FUT2 polymorphism appear to be key drivers affecting the individual variation of human intestinal microbiota.
Also cumulative risk of acute graft vs host disease was decreased in those with A/A genotype and cumulative incidence of bacteremia was increased in A/A genotype following allogenic stem cell transplant2
Vitamin D
Vitamin D helps your body absorb calcium. Calcium is one of the main building blocks of bone. A lack of vitamin D can lead to bone diseases such as osteoporosis or rickets. Vitamin D also has a role in your nerve, muscle, and immune systems.
You can get vitamin D in three ways: through your skin, from your diet, and from supplements. Your body forms vitamin D naturally after exposure to sunlight. However, too much sun exposure can lead to skin aging and skin cancer. So many people try to get their vitamin D from other sources.
Vitamin D-rich foods include egg yolks, saltwater fish, and liver. Some other foods, like milk and cereal, often have added vitamin D.
Sun exposure, diet and genetic factors determine the of levels of 25-hydroxyvitamin D in the body.
The CYP2R1 gene encodes for Vitamin D 25-hydroxylase. This enzyme is responsible for converting Vitamin D3 (found in the diet and in supplements) into 25-OH D3 (The major circulating form of Vitamin D in the body)
Your Genetics
Gene variation
Genotype
Phenotype
CYP2R1 rs10741657
-
CYP2R1 rs12794714
AG
+/-
Laurent75 has insufficient genotypes to determine response for Vitamin D
22% of people with African ancestry carry the A allele for rs10741657
Vitamin B12
Vitamin B12 is used for treating and preventing vitamin B12 deficiency, a condition in which vitamin B12 levels in the blood are too low. It is also used to treat pernicious anemia, a serious type of anemia that is due to vitamin B12 deficiency and is found mostly in older people. For this purpose, people use either a supplement that is taken by mouth or a gel that is applied inside the nose.
Vitamin B12 is also used for memory loss; Alzheimer s disease; boosting mood, energy, concentration and the immune system; and slowing aging. It is also used for heart disease, lowering high homocysteine levels (which may contribute to heart disease), male infertility, diabetes, sleep disorders, depression, mental disorders, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory bowel disease, asthma, allergies, a skin disease called vitiligo, preventing cervical and other cancers, and skin infections.
Some people use vitamin B12 for amyotrophic lateral sclerosis (Lou Gehrig s disease), multiple sclerosis, preventing the eye disease age-related macular degeneration (AMD), Lyme disease and gum disease. It is also used for ringing in the ears, bleeding, liver and kidney disease, and for protection against the poisons and allergens in tobacco smoke.
Polymorphisms in the FUT2 gene are associated with Vitamin b12 blood levels
Your Genetics
Gene variation
Genotype
Phenotype
FUT2 rs602662
AA
+/+
Laurent75 has decreased ability to absorb vitamin B12 through the intestine, due to AA genotype for rs602662 compared to people with other genotypes. Other clinical, genetic or environmental factors may influence this outcome.
People with homozygotes (AA) and heterozygotes (AG) polymorphisms in the FUT2 gene have 15% lower vitamin B12 levels because it is not efficiently absorbed in their intestines. People with this mutation would need to take a sublingual form of the vitamin for better absorption
49% of people with African ancestry carry the A allele for rs602662
Vitamin B6
Vitamin B6 is used for preventing and treating low levels of pyridoxine (pyridoxine deficiency) and the tired blood (anemia) that may result. It is also used for heart disease; high cholesterol; reducing blood levels of homocysteine, a chemical that might be linked to heart disease; and helping clogged arteries stay open after a balloon procedure to unblock them (angioplasty).
Women use vitamin B6 for premenstrual syndrome (PMS) and other menstruation problems, "morning sickness" (nausea and vomiting) in early pregnancy, stopping milk flow after childbirth, depression related to pregnancy or using birth control pills, and symptoms of menopause.
Vitamin B6 is also used for Alzheimer's disease, attention deficit-hyperactivity disorder (ADHD), Down syndrome, autism, diabetes and related nerve pain, sickle cell anemia, migraine headaches, asthma, carpal tunnel syndrome, night leg cramps, muscle cramps, arthritis, allergies, acne and various other skin conditions, and infertility.
The NBPF3 gene has been associated with vitamin B6. People who have a homozygous mutation in this gene tend to have lower levels of vitamin B6.
Your Genetics
Gene variation
Genotype
Phenotype
NBPF3 rs4654748
CT
+/-
NBPF3 - rs4654748: In the InCHIANTI study, the presence of the C allele was associated with 1.38 ng/mL lower vitamin B6 concentrations. This association was replicated in the Progetto Nutrizione study1
Laurent75 is likely to have reduced levels of vitamin B6, due to TC genotype for rs4654748 compared to people with other genotypes. Other clinical, genetic or environmental factors may influence this outcome.
People with this type of polymorphism tend to have lower levels of vitamin B6, and may need to increase dietary intake of vitamin B6, and/or supplement with Vitamin B6. Homozygotes (CC genotype) have approximately 2.90 ng/mL lower Vitamin B6 blood concentration, while heterozygotes (TC genotype), have 1.45 ng/mL lower Vitamin B6 blood concentration. In replicated studies, the presence of the C allele was associated with 1.38 ng/mL lower vitamin B6 concentrations.
Vitamin B6 is found in Avocado, Banana, Legumes (dried beans), Meat, Nuts, Poultry and Whole grains
94% of people with African ancestry carry the C allele for rs4654748
Folate and the MTHFR gene
Folic acid is a type of B vitamin. It is the synthetic form of folate that is found in supplements and added to fortified foods. Folate is a generic term for both naturally occurring folate found in foods and folic acid. Folic acid is not stored in the body and you need a continuous supply of the vitamin in the foods you eat. Folate occurs naturally in dark green leafy vegetables, dried beans and peas (legumes), citrus fruits and juices.
One of the most important uses of folate in the body, is as a precursor of methyl groups. Methyl groups are needed for many biochemical reactions in the body, and also for turning genes on and off. (Epigenetics)
The MTHFR gene encodes an enzyme that is critical in the metabolism of folate. People who are deficient in this enzyme are unable to convert folic acid to its active forms in the body, and as a result, have a build up of toxic by-products such as Homocysteine, which has been associated with heart disease and dementia.
Your Genetics
Gene variation
Genotype
Phenotype
MTHFR A1298C rs1801131
GT
+/-
MTHFR C677T rs1801133
GG
-/-
Laurent75 has reduced MTHFR enzyme activity, due to GT genotype for rs1801131 compared to people with other genotypes. Other clinical, genetic or environmental factors may influence this outcome.
Reduced function of this gene prevents people from converting dietary folate or supplemental folic acid into active forms. It also causes higher levels of homocysteine which is associated with diseases such as stroke, vascular dementia and coronary artery disease.
Supplementation with L5-Methyl Folate has been shown to lower homocysteine by 15% in those affected by MTHFR C677T rs1801133.
Supplementation with Vitamin B12 and Vitamin B2 are also useful because, Methyl cobalamin (a form of Vitamin B12) is a cofactor of methionine synthetase which converts homocysteine to methionine. RIboflavin (Vitamin B2) is a cofactor of MTHFR, stabilizing the enzyme and increasing its efficiency.
9% of people with African ancestry carry the A allele for rs1801133
Kidney disease risk and MTHFS gene
The Kidneys filter wastes and excess water out of your blood to make urine. They also keep the body's chemical balance, help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged and can't filter blood as they should. This damage can cause wastes to build up in your body. It can also cause other problems that can harm your health. CKD can get worse over time and may lead to kidney failure. The only treatment options for kidney failure are dialysis or a kidney transplantation.
Diabetes and high blood pressure are the most common causes of CKD. Other causes include genetic problems, injuries, or medicines. Genome-wide association study (GWAS) have provided unbiased information implicating MTHFS as a candidate gene for kidney disease. Meta-analysis of a large study (Framingham Heart Study) showed a variant of the MTHFS gene was significantly associated with CKD. In this study, Caucasians with the C allele of MTHFS rs6495446 were more likely than people without this variant, to have CKD.
Your Genetics
Gene
variation
Genotype
Phenotype
MTHFS rs6495446
CC
-/-
MTHFS - rs6495446: This genome-wide association study provides unbiased information implicating MTHFS as a candidate gene for kidney disease1 This genome-wide association study provides unbiased information implicating MTHFS as a candidate gene for kidney disease1
Laurent75 has increased risk of developing Chronic Kidney Disease, due to CC genotype for rs6495446 compared to people with other genotypes. Other clinical, genetic or environmental factors may influence this outcome.
People who are homozygous (CC) for MTHFS rs6495446 were 2.5 times more likely than people without this variant, to have CKD. In this study1, risk for CKD was dependent on the presence of the C allele, and was increased by 1.24 times per C allele.
51% of people with African ancestry carry the C allele for rs6495446
nakyla a écrit:23andme fournit déjà pas mal d'indication sur des risques augmentés ou diminués de pas mal de maladies.
Tollecausam a écrit:Il se trouve que mon attention revient sur les BCAA en ce moment (après quelques prises à faibles doses il y a 2 ans sans résultats marquants). J'ai lu plusieurs autres retours positifs sur des forums US avec des dosages plus élevés et j'en ai commandé pour faire ma propre expérience. Je vous tiendrai informés du résultat.
Tollecausam a écrit:Bonsoir Laurent,
Merci de ce témoignage très intéressant.
Il se trouve que mon attention revient sur les BCAA en ce moment (après quelques prises à faibles doses il y a 2 ans sans résultats marquants). J'ai lu plusieurs autres retours positifs sur des forums US avec des dosages plus élevés et j'en ai commandé pour faire ma propre expérience. Je vous tiendrai informés du résultat.
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